In adults with overweight or obesity and at least one related health condition, a weekly injection of pemvidutide for 48 weeks resulted in an average weight loss of 15.6%, compared to 2.2% with a...
Mechanism
Synthesis from 1 study
This drug works by making you feel full faster and helping your liver burn more fat for energy. Together, that means you eat less and burn more, so you lose weight over time.
Most probable mechanism
This medicine binds to two special receptors in the body: one that tells the brain you're full, and another that makes the liver burn more fat and energy. Together, this makes you eat less and burn more calories, so you lose weight.
Pemvidutide binds to and activates GLP-1 receptors on neurons in the hypothalamus, reducing hunger signals
Activation of GLP-1 receptors increases satiety, leading to reduced caloric intake
Pemvidutide simultaneously activates glucagon receptors on hepatocytes, increasing hepatic fat oxidation and energy expenditure
Combined effects of reduced energy intake and increased energy expenditure create a sustained negative energy balance
Evidence from Studies
Supporting (1)
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Contradicting (0)
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Gold Standard Evidence Needed
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