Fit Body ScienceEvidence-based fitness analysis

Berberine supplementation does not reduce belly fat or liver fat in adults with obesity and MASLD compared to a placebo.

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Supplementation with berberine does not reduce visceral adipose tissue or liver fat compared to placebo in adults with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD).

Supporting1 study

Very strong evidence

Randomized trials

One good-quality study supports this claim.

What the research says

1 study reviewed

Supporting (1)

Strong

Contradicting (0)

None

No contradicting studies found yet

That doesn't mean it's settled — it just means no study has tested the opposite.

Quality-weighted scoring: we follow the GRADE framework — each study is rated High, Moderate, Low, or Very Low based on study design, methodology rigor, and risk of bias. A single high-quality RCT can outweigh several weaker observational studies.

Scores reflect study quality, not just count.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting study

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