The Claim
Oral administration of Lactobacillus casei expressing a modified human myostatin protein (BLS-M22) in 32-week-old male mdx mice is associated with a significant increase in systemic anti-myostatin IgG antibodies and a reduction in serum creatine kinase levels, but does not significantly alter muscle fiber size or fibrosis in advanced-stage Duchenne muscular dystrophy.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In 32-week-old male mdx mice with advanced Duchenne muscular dystrophy, oral treatment with Lactobacillus casei expressing a modified human myostatin protein increases anti-myostatin antibodies and lowers serum creatine kinase levels, but does not change muscle fiber size or fibrosis.
See the scientific wording
Oral administration of Lactobacillus casei expressing a modified human myostatin protein (BLS-M22) in 32-week-old male mdx mice is associated with a significant increase in systemic anti-myostatin IgG antibodies and a reduction in serum creatine kinase levels, suggesting attenuated muscle damage, but does not significantly alter muscle fiber size or fibrosis in advanced-stage Duchenne muscular dystrophy.
A probiotic carrying a modified version of a muscle-limiting protein is swallowed, and the immune system in the gut recognizes it as foreign. This causes the body to make antibodies that circulate in the blood and block the muscle-limiting protein. When the protein is blocked, muscle cells become less likely to tear during use, so fewer muscle enzymes leak into the blood. This does not repair damaged muscle tissue or reduce scarring.
What the research says
1 studyScientists gave mice with a muscle disease a special probiotic that tricks their body into making antibodies against a muscle-limiting protein. This helped reduce muscle damage and made the mice run longer, but didn’t make their muscles bigger or less scarred — just like the claim said.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.