mechanistic
Analysis v1
Strong Support
When rats have too much uric acid in their blood, their blood vessels don't respond as well to insulin because key signals inside the cells aren't working right and less of a helpful blood vessel chemical (nitric oxide) is made.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis
Cross-Sectional Study
Animal
2014 JulThe study shows that high uric acid levels in rats mess up how blood vessels respond to insulin by blocking key signals that help blood vessels relax, which supports the idea that high uric acid causes blood vessel problems.
Contradicting (0)
0
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No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.