Scientists found that giving a plant compound called 8-prenylnaringenin to female rats without ovaries, at a specific dose for three days, made more little bud-like structures grow in their mammary glands than two other similar compounds did.

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Evidence from Studies

Supporting (1)

8

Community contributions welcome

8

Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland.

Cross-Sectional Study

Animal

2014 Jul 5

The study gave 8-prenylnaringenin to rats with their ovaries removed and found it increased the number of terminal end buds in the mammary gland more than the other two compounds tested (6-DMAN and naringenin), exactly matching what the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland.

Score: 8

DOI: 10.1016/j.mce.2014.05.014

Similar Assertions

This claim is about a compound called 8-prenylnaringenin (found in hops) and how it affects the uterus and uterine lining in rats that had their ovaries removed. The claim says it has very small growth effects on these tissues, and importantly, these effects don't change no matter how much of the compound is given.

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