The Claim
In ovariectomized ewes, intravenous administration of endotoxin at a dose of 400 ng/kg significantly increases cortisol levels (P < 0.001), progesterone levels (P < 0.01), and core body temperature (P < 0.001).
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In sheep without ovaries, a single intravenous injection of endotoxin at 400 ng/kg causes measurable increases in cortisol, progesterone, and body temperature.
See the scientific wording
In ovariectomized ewes, intravenous endotoxin (400 ng/kg) significantly increases cortisol levels (P < 0.001), progesterone levels (P < 0.01), and core body temperature (P < 0.001), indicating concurrent activation of the adrenal stress response and febrile system.
Toxins in the blood trigger the brain to release stress hormones and raise body temperature, while simultaneously shutting down signals that control reproduction. The stress hormones are made by the adrenal glands in response to brain signals, and the fever results from the brain adjusting the body's temperature set point.
What the research says
1 studyIn female sheep without ovaries, a single shot of endotoxin made their stress hormones and body temperature go up, just like the claim says. This proves their body kicked into high gear to fight inflammation.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.