In teenage girls who don’t have diabetes or anemia, red blood cell creatine goes up as they get older, especially after puberty—but this doesn’t happen in boys. This rise isn’t linked to blood sugar levels.

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Pro

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Against

Evidence from Studies

Supporting (1)

36

Community contributions welcome

36

Elevation of erythrocyte creatine post-puberty unrelated to erythrocyte lifespan: Implications from the lack of correlation between HbA1c and erythrocyte creatine.

Cross-Sectional Study

Human

2025 Feb 15

The study found that red blood cell creatine goes up in teenage girls as they get older, but not in boys, and this isn't related to blood sugar levels—just like the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Elevation of erythrocyte creatine post-puberty unrelated to erythrocyte lifespan: Implications from the lack of correlation between HbA1c and erythrocyte creatine.

Score: 36

DOI: 10.1016/j.cca.2025.120130

Similar Assertions

In kids who don’t have diabetes or anemia, red blood cell creatine doesn’t seem to track with average blood sugar levels, so it might not be a good way to measure sugar exposure over time.

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81%

Girls who have started their periods tend to have higher levels of creatine in their red blood cells compared to those who haven’t, and this doesn’t seem to be because of differences in blood sugar control.

36

0

77%