The Claim
In adult humans, the production rate of reverse-T3 from thyroxine is approximately 34 micrograms per day and is comparable to the production rate of T3 (20-24 micrograms per day), indicating that extrathyroidal conversion of thyroxine is a major metabolic pathway for both hormones.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In adult humans, about 34 micrograms of reverse-T3 are produced daily from thyroxine, which is similar to the amount of T3 produced daily (20-24 micrograms), showing that the conversion of thyroxine outside the thyroid gland is a major source of both hormones.
See the scientific wording
In adult humans, the production rate of reverse-T3 from thyroxine is approximately 34 microng/day and is comparable to the production rate of T3 (20-24 microng/day), indicating that extrathyroidal conversion of thyroxine is a major metabolic pathway for both hormones.
The thyroid releases thyroxine into the blood, and tissues like the liver, kidney, and muscle take it up and remove iodine atoms from it in two different ways: one way makes the active hormone T3, and the other way makes reverse-T3. These two processes happen at similar rates, so the body produces almost as much reverse-T3 as T3 without help from the thyroid.
What the research says
1 studyThe study found that the body turns thyroid hormone into two different forms outside the thyroid gland, and it makes slightly more of the reverse form than the active form — meaning most of these hormones aren’t made by the thyroid at all, but by other parts of the body.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.