The Claim

Administration of ACE-031 at a dose of 3.0 mg/kg weekly for 14 weeks in healthy adult common marmosets is associated with a significant increase in lean body mass and a 20% greater cross-sectional area of type II muscle fibers and a 34% greater area of type I fibers in the biceps brachii, suggesting that dual inhibition of myostatin and activin A promotes skeletal muscle hypertrophy in non-human primates.

Source: ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus)

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
16score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In healthy adult common marmosets, weekly injections of ACE-031 for 14 weeks result in increased lean body mass and larger type I and type II muscle fibers in the biceps brachii.

See the scientific wording

Administration of ACE-031, a soluble activin type IIB receptor fusion protein, at a dose of 3.0 mg/kg weekly for 14 weeks in healthy adult common marmosets is associated with a significant increase in lean body mass, with mean increases observed from baseline to week 14, and a 20% greater cross-sectional area of type II muscle fibers and 34% greater area of type I fibers in the biceps brachii, suggesting that dual inhibition of myostatin and activin A promotes skeletal muscle hypertrophy in non-human primates.

Why this might work

A protein trap blocks two natural signals that limit muscle growth, allowing muscle cells to build more protein and break down less, causing muscle fibers to get larger and the body to gain lean mass.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus)

    In monkeys, a weekly shot of ACE-031 for 14 weeks made their muscles bigger and stronger without adding fat, proving that blocking certain natural brakes on muscle growth works in primates.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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