The Claim

In healthy young adult males, the serum cortisol nadir at approximately 0400 h is followed by a decline in serum osteocalcin levels approximately 4 hours later, indicating a phase-dependent temporal relationship between these two hormones.

Source: Inhibition of the morning cortisol peak abolishes the expected morning decrease in serum osteocalcin in normal males: evidence of a controlling effect of serum cortisol on the circadian rhythm in serum osteocalcin.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
39score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In healthy young men, the lowest level of cortisol in the blood around 4 a.m. is followed by a drop in osteocalcin levels about four hours later.

See the scientific wording

In healthy young adult males, the serum cortisol nadir occurring around 0400 h is temporally linked to a subsequent decline in serum osteocalcin approximately 4 hours later, suggesting a phase-dependent regulatory relationship between these two hormones.

Why this might work

When cortisol levels drop to their lowest point in the early morning, osteoblasts in the bone stop being suppressed, but this release is delayed by about four hours. After that delay, osteoblasts reduce their production of osteocalcin, causing its blood levels to fall.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Inhibition of the morning cortisol peak abolishes the expected morning decrease in serum osteocalcin in normal males: evidence of a controlling effect of serum cortisol on the circadian rhythm in serum osteocalcin.

    In healthy young men, cortisol drops to its lowest point around 4 a.m., and about four hours later, osteocalcin normally drops too — like a domino effect. When scientists blocked the morning cortisol rise, this osteocalcin drop didn’t happen, proving the two are timed together.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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