mechanistic
Analysis v1
Strong Support
Uric acid messes with blood vessel relaxation in human cells more than it affects blood vessel tightening, which might explain how it harms blood flow.
8
0
Evidence from Studies
Supporting (1)
8
Community contributions welcome
8
Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis
Cross-Sectional Study
Animal
2014 JulThe study shows that uric acid blocks the blood vessel-relaxing effects of insulin more than it affects blood vessel tightening, which matches the claim.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.