The Claim
Human liver microsomes contain a deiodinase enzyme that catalyzes both outer ring deiodination of reverse T3 and inner ring deiodination of T3 sulfate with similar efficiency, demonstrating a single enzymatic mechanism for both reactions.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Human liver microsomes contain an enzyme that removes iodine from reverse T3 and T3 sulfate in the same way and at the same rate, indicating one enzyme performs both reactions.
See the scientific wording
Human liver microsomes contain a deiodinase enzyme that catalyzes both outer ring deiodination of reverse T3 and inner ring deiodination of T3 sulfate with similar efficiency, demonstrating a single enzymatic mechanism for both reactions.
A single enzyme in liver cells removes iodine atoms from two different thyroid hormone molecules using the same chemical process, breaking one type of bond in one molecule and a different bond in another, but always using the same tool and same steps.
What the research says
1 studyStudy: Deiodination of thyroid hormone by human liver.
Scientists found that one enzyme in the liver breaks down two different thyroid hormones in the same way, using the same chemical process and being blocked by the same inhibitor — like one key fitting two locks the same way.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.