The Claim
The deiodination rate of T3 sulfate in human liver microsomes is approximately 30 times faster than the deiodination rate of unsulfated T3, indicating that sulfation enhances substrate recognition by deiodinase enzymes.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In human liver tissue, T3 sulfate is converted by deiodinase enzymes about 30 times faster than unsulfated T3, showing that the addition of a sulfate group increases the enzyme's efficiency in processing this hormone.
See the scientific wording
The deiodination of T3 sulfate occurs approximately 30 times faster than that of unsulfated T3 in human liver microsomes, indicating sulfation significantly enhances substrate recognition by the deiodinase enzyme.
Adding a sulfate group to the thyroid hormone makes it fit much better into the liver enzyme that removes iodine, so the enzyme can break it down 30 times faster than the unsulfated version.
What the research says
1 studyStudy: Deiodination of thyroid hormone by human liver.
Scientists found that when a sulfate group is added to a thyroid hormone, the liver breaks it down about 30 times faster than the normal version — meaning the sulfate tag makes it easier for the liver’s enzyme to recognize and remove it.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.