mechanistic
Analysis v1
Strong Support
In male mice, prolonged social stress is linked to lower levels of GABA and higher levels of glutamate in a brain region called the hypothalamus, which may disrupt normal brain signaling and lead to lasting anxiety-like behaviors, similar to changes seen in humans with major depression.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Scientists gave mice repeated social stress and found their brains had less of a calming chemical (GABA) and more of a stimulating one (glutamate), making them act more anxious — just like people with depression often show similar brain changes.
Contradicting (0)
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No contradicting evidence found
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