The Claim
Chronic social defeat stress in male mice is associated with suppressed corticosterone synthesis in the adrenal gland due to down-regulation of steroidogenic enzymes including Star, Cyp11a1, and Hsd3b1, while acute stress induces a transient increase in corticosterone production, indicating a shift from adaptive to maladaptive HPA-axis regulation.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In male mice, prolonged social stress reduces the production of the stress hormone corticosterone in the adrenal gland by decreasing the activity of specific enzymes involved in its synthesis, whereas short-term stress temporarily increases corticosterone levels, suggesting a change in how the stress response system functions over time.
See the scientific wording
Chronic social defeat stress in male mice is associated with suppressed synthesis of corticosterone in the adrenal gland, driven by down-regulation of key steroidogenic enzymes (e.g., Star, Cyp11a1, Hsd3b1), whereas acute stress triggers a transient increase in corticosterone production, indicating a shift from adaptive to maladaptive HPA-axis regulation.
What the research says
1 studyWhen mice are bullied over and over, their stress hormone production drops over time, making them less able to handle stress — but a single bullying event makes them temporarily more stressed. This study shows how long-term stress breaks the body’s stress system.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.