In male rats, a hormone called GIP can block insulin’s ability to increase blood flow to leg muscles, even when insulin levels stay the same — suggesting GIP directly interferes with how insulin works in the blood vessels of muscle.

12

Pro

0

Against

Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

Cross-Sectional Study

Animal

The study shows that giving GIP to rats blocks insulin’s ability to increase blood flow in muscle, just like the claim says, and doesn’t change insulin levels.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

Score: 12

DOI: 10.2337/db24-109-or

Similar Assertions

In male rats, a hormone called GIP can completely stop another hormone, GLP-1, from increasing blood flow to leg muscles—even if the rats eat junk food or regular food—and it does this without changing how much GLP-1 is in the blood.

12

0

80%

In male rats, insulin helps blood flow to leg muscles pretty quickly—but only if they're eating regular food. If they're on a high-fat diet, insulin doesn't do this job well anymore.

12

0

79%

When the tiny blood vessels in muscles don't respond well to insulin, it's linked to being overweight, having insulin resistance, and getting older — and this might actually happen before the muscle cells themselves become resistant to insulin.

2

0

70%