In male rats, a hormone called GIP can block insulin’s ability to increase blood flow to leg muscles, even when insulin levels stay the same — suggesting GIP directly interferes with how insulin...

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Evidence from Studies

Supporting (1)

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109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

Cross-Sectional Study

Animal & In Vitro

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No contradicting evidence found

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Source Study

109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

Score: 12

DOI: 10.2337/db24-109-or

Similar Assertions

In male rats, a hormone called GIP can completely stop another hormone, GLP-1, from increasing blood flow to leg muscles—even if the rats eat junk food or regular food—and it does this without changing how much GLP-1 is in the blood.

80%

In male rats, insulin helps blood flow to leg muscles pretty quickly—but only if they're eating regular food. If they're on a high-fat diet, insulin doesn't do this job well anymore.

79%

When the tiny blood vessels in muscles don't respond well to insulin, it's linked to being overweight, having insulin resistance, and getting older — and this might actually happen before the muscle cells themselves become resistant to insulin.

70%