In male rats, a hormone called GIP can completely stop another hormone, GLP-1, from increasing blood flow to leg muscles—even if the rats eat junk food or regular food—and it does this without changing how much GLP-1 is in the blood.

12

Pro

0

Against

Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

Cross-Sectional Study

Animal

The study shows that when GIP is given with GLP-1, it stops GLP-1 from increasing blood flow to muscle in rats, just like the claim says. This happens no matter if the rats eat regular food or fatty food.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

Score: 12

DOI: 10.2337/db24-109-or

Similar Assertions

In male rats, a hormone called GIP can block insulin’s ability to increase blood flow to leg muscles, even when insulin levels stay the same — suggesting GIP directly interferes with how insulin works in the blood vessels of muscle.

12

0

80%

When healthy adults get a specific dose of a hormone called GLP-1 through an IV, it quickly boosts blood flow in the small vessels of their heart and muscles, helping deliver more nutrients and hormones where they're needed.

54

0

79%

When healthy adults get both GLP-1 and insulin at the same time, it doesn’t boost blood flow to their heart or muscles any more than using just one of the hormones alone.

54

0

74%