In mice on a high-fat diet, a drug called GW501516 might help liver cells better manage fat by turning up a key protein and activating a fat-burning switch.

12

Pro

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Against

Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Cross-Sectional Study

Animal

2011 May

The study shows that the drug GW501516 increases a key protein in liver cells that helps burn fat more efficiently in mice on a high-fat diet, which is exactly what the claim says.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Score: 12

DOI: 10.1210/en.2010-1468

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