The Claim

In adult male C57BL/6J mice, plasma corticosterone levels peak during the light phase and are correlated with REDD1 expression in skeletal muscle, indicating that systemic circadian hormone rhythms are associated with altered muscle anabolic signaling sensitivity.

Source: Time-of-day effect of high-intensity muscle contraction on mTOR signaling and protein synthesis in mice

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
9score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In male C57BL/6J mice, corticosterone levels in the blood are highest during the day and coincide with increased REDD1 protein levels in muscle tissue, suggesting a link between daily hormone cycles and changes in how muscle responds to growth signals.

See the scientific wording

In adult male C57BL/6J mice, plasma corticosterone levels peak during the light phase and correlate with REDD1 expression in muscle, suggesting systemic circadian hormones may influence muscle anabolic signaling sensitivity.

Why this might work

During the day, a hormone called corticosterone rises in the blood, which causes a muscle protein called REDD1 to increase at night. When REDD1 is high, it blocks a key growth signal in muscle cells called mTORC1. When REDD1 drops during the day, the growth signal turns on more strongly, allowing muscle cells to build more protein. Muscle activity during the day further reduces REDD1, making the growth signal even stronger.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Time-of-day effect of high-intensity muscle contraction on mTOR signaling and protein synthesis in mice

    In mice, the stress hormone corticosterone is higher during their sleep time, and so is a muscle protein called REDD1 that helps control how muscles respond to exercise. The study shows REDD1 goes up when muscles are less active, suggesting the body’s daily rhythm might help decide when muscles are most ready to grow.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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