mechanistic
Analysis v1
Strong Support
In mice and rats, a specific protein called THRA is the main way thyroid hormone works in the testes. If this protein is missing or broken, the damage caused by too much thyroid hormone goes away—meaning THRA is needed for the hormone to affect the cells that make sperm and testosterone.
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0
Evidence from Studies
Supporting (1)
1
Community contributions welcome
1
Thyroid Hormone Deiodination and Action in the Gonads.
Narrative Review
Human
2018 OctThe study says THRA is one of the main ways thyroid hormone works in the testis, which matches the claim that THRA is the key player there — even if it didn’t test what happens when you break THRA.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.