If you remove certain enzymes in mice, they don't get fatty livers from eating fructose — suggesting those enzymes are needed for fructose to cause harm.

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Recent Progress on Fructose Metabolism—Chrebp, Fructolysis, and Polyol Pathway

Narrative Review

Human

2023 Apr 5

The study shows that when mice are genetically changed so they don’t have certain enzymes, they don’t get fatty livers from eating fructose—just like the claim says.

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Source Study

Recent Progress on Fructose Metabolism—Chrebp, Fructolysis, and Polyol Pathway

Score: 1

DOI: 10.3390/nu15071778

Similar Assertions

When scientists block a specific enzyme in mice that breaks down fructose (a sugar), the mice’s livers work better and store less fat—suggesting that how the body processes fructose might be what causes the damage.

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If people eat a lot of fructose, their body breaks it down in the gut and liver, and that process can turn the sugar into fat, which may build up in the liver over time.

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Eating a lot of fructose (like in sugary drinks) might turn up the activity of certain liver enzymes that process sugar and make fat, especially in people who already have metabolic problems like obesity or diabetes.

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