When scientists block a specific enzyme in mice that breaks down fructose (a sugar), the mice’s livers work better and store less fat—suggesting that how the body processes fructose might be what causes the damage.

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Fructose and hepatic insulin resistance

Narrative Review

Human

2020 Aug

When scientists blocked the enzyme that breaks down fructose in mice, their livers became more sensitive to insulin and had less fat — proving that fructose’s harmful effects need this enzyme to happen.

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Source Study

Fructose and hepatic insulin resistance

Score: 1

DOI: 10.1080/10408363.2019.1711360

Similar Assertions

If people eat a lot of fructose, their body breaks it down in the gut and liver, and that process can turn the sugar into fat, which may build up in the liver over time.

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If you remove certain enzymes in mice, they don't get fatty livers from eating fructose — suggesting those enzymes are needed for fructose to cause harm.

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Eating a lot of fructose (like in sugary drinks) might turn up the activity of certain liver enzymes that process sugar and make fat, especially in people who already have metabolic problems like obesity or diabetes.

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