In mice with heart damage from interrupted blood flow, a diabetes drug called dapagliflozin helps calm down inflammation in tiny blood vessels and stops heart cells from dying too soon.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

8

SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways

Randomized Controlled Trial

Animal

2022

The study found that dapagliflozin helps protect tiny blood vessels in the heart after a heart attack in mice by keeping heart cells alive and reducing damage — which matches the claim, even if it explains how in a slightly different way.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways

Score: 8

DOI: 10.7150/thno.75121

Similar Assertions

When scientists remove a specific protein (SERCA2) from blood vessel cells in mice with heart damage, a diabetes drug called dapagliflozin no longer helps protect those blood vessels, reduce swelling, or keep the cells alive.

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A diabetes drug called dapagliflozin may help protect heart blood vessels from damage caused by temporary lack of oxygen and then sudden return of blood flow, by calming down a harmful enzyme, keeping a key protein from getting damaged, and helping cells manage calcium properly — which keeps the vessel lining intact and stops cells from dying.

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86%

A diabetes drug called dapagliflozin may help protect heart blood vessel cells from damage after a heart attack by stopping certain harmful chemical signals, which keeps the cells’ internal structure intact and prevents them from dying.

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82%

In rats that had a heart attack, a drug called dapagliflozin helped them live longer and made their hearts pump better, according to ultrasound scans.

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78%

When heart blood vessel cells are stressed by low oxygen and then get oxygen back, a diabetes drug called dapagliflozin helps them heal better by calming down harmful stress and fixing their internal calcium levels.

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77%