When scientists remove a specific protein (SERCA2) from blood vessel cells in mice with heart damage, a diabetes drug called dapagliflozin no longer helps protect those blood vessels, reduce swelling, or keep the cells alive.

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Evidence from Studies

Supporting (1)

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SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways

Randomized Controlled Trial

Animal

2022

The study found that when mice lack a specific protein (SERCA2) in their blood vessel cells, the drug dapagliflozin can no longer protect their heart vessels after a heart attack. This proves the drug needs that protein to work.

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Source Study

SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways

Score: 8

DOI: 10.7150/thno.75121

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