mechanistic
Analysis v1
Strong Support
In mice with kidney injury caused by cisplatin, taking selenomethionine by mouth lowers levels of biomarkers associated with kidney damage and improves tissue appearance under a microscope, which is linked to higher levels of the enzyme GPX4 in the kidneys.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity
Randomized Controlled Trial
Animal & In Vitro
2026 Feb 14Giving mice a selenium-containing compound called selenomethionine helped protect their kidneys from damage caused by a chemotherapy drug, by boosting a natural antioxidant enzyme and reducing harmful oxidative stress.
Contradicting (0)
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No contradicting evidence found
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