When scientists added a form of vitamin D along with leucine and insulin to muscle cells from mice, the cells made more protein than usual—about 14 to 16% more—suggesting these three things work better together than alone.

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Evidence from Studies

Supporting (1)

9

Community contributions welcome

9

1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

Cross-Sectional Study

Animal

2013 Dec

The study found that when mouse muscle cells are given vitamin D along with leucine and insulin, they make more protein — exactly as the claim says. The numbers and conditions match perfectly.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

Score: 9

DOI: 10.1002/mnfr.201300074

Similar Assertions

When scientists add a form of vitamin D to mouse muscle cells in a dish, the cells start making more of two important proteins: one that helps them respond to insulin, and one that helps them respond to vitamin D itself.

9

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82%

In muscle cells from mice, a form of vitamin D makes the cells respond stronger to leucine and insulin, which are signals that tell the body to build muscle — so it might help muscles grow better.

9

0

81%

When muscle cells from humans are treated with a specific form of vitamin D for five days, they become more active in building proteins — especially when insulin is also around.

3

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80%