The Claim
In murine C2C12 skeletal myotubes, treatment with 1,25(OH)2-vitamin D3 at a concentration of 10 nM in combination with leucine and insulin increases the protein fractional synthesis rate by 14–16%, demonstrating a synergistic effect on muscle protein production in this in vitro cell model.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When scientists added a form of vitamin D along with leucine and insulin to muscle cells from mice, the cells made more protein than usual—about 14 to 16% more—suggesting these three things work better together than alone.
See the scientific wording
In murine C2C12 skeletal myotubes, 1,25(OH)2-vitamin D3 at 10 nM enhances the protein fractional synthesis rate by 14–16% when combined with leucine and insulin, indicating a synergistic effect on muscle protein production in this cell model.
What the research says
1 studyThe study found that when mouse muscle cells are given vitamin D along with leucine and insulin, they make more protein — exactly as the claim says. The numbers and conditions match perfectly.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.