The Claim

In human immortalized myoblast cells under oxidative stress, oleuropein aglycone increases phosphorylation of FOXO3a at Ser413 and decreases phosphorylation at Ser253.

Source: Oleuropein Aglycone Modulates Oxidative Stress and Autophagy‐Related Pathways in Human Skeletal Muscle Cells

What the research says

Roughly balanced

Support and challenge are close. The picture may shift as more studies come in.

Supports
6score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In human muscle precursor cells exposed to oxidative stress, oleuropein aglycone alters the phosphorylation state of the FOXO3a protein at two specific sites, which is associated with increased activity of this protein in stress response pathways.

See the scientific wording

In human immortalized myoblast cells under oxidative stress, oleuropein aglycone increased phosphorylation of FOXO3a at Ser413 (an AMPK-mediated site) and decreased phosphorylation at Ser253 (an AKT-mediated site), suggesting a shift toward FOXO3a activation and enhanced stress resistance.

What the research says

1 study

  1. Study: Oleuropein Aglycone Modulates Oxidative Stress and Autophagy‐Related Pathways in Human Skeletal Muscle Cells

    Oleuropein aglycone, a compound from olive leaves, helps muscle cells fight stress by turning on protective pathways that keep cells healthy. The study shows it works in a way that matches the claim, even if it didn’t measure every exact detail.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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