The Claim
In 10 obese adults undergoing 7 days of 240 kcal/day caloric restriction, tissue uptake of thyroxine (T4) and triiodothyronine (T3) is significantly reduced, with mass transfer to rapidly and slowly equilibrating tissue pools diminished by approximately 50%, indicating impaired transmembrane transport independent of serum hormone concentration changes.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
During a 7-day very low-calorie diet in obese adults, the movement of thyroid hormones into body tissues decreases by about half, regardless of hormone levels in the blood.
See the scientific wording
In 10 obese adults undergoing 7 days of 240 kcal/day caloric restriction, tissue uptake of thyroxine (T4) and triiodothyronine (T3) is significantly reduced, with mass transfer to rapidly and slowly equilibrating tissue pools diminished by approximately 50%, indicating impaired transmembrane transport independent of serum hormone concentration changes.
When the body gets very little food, it reduces the number of special gates on cell surfaces that pull thyroid hormones from the blood into tissues. This means less hormone enters cells, even though the amount in the blood stays mostly the same, leading to lower hormone levels inside tissues.
What the research says
1 studyStudy: Effects of caloric deprivation on thyroid hormone tissue uptake and generation of low-T3 syndrome.
When obese people ate very few calories for a week, their bodies got worse at pulling thyroid hormones from the blood into tissues — even though the hormone levels in the blood didn’t drop much. This means the cells’ ability to absorb these hormones was slowed down.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.