The Claim

Plasma Maresin-1 levels are negatively correlated with fasting insulin, glucose, and HOMA-IR in obese men, with correlation coefficients of -0.579, -0.548, and -0.599, respectively.

Source: 12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
81score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In obese men, higher levels of Maresin-1 in the blood are associated with lower levels of fasting insulin, glucose, and insulin resistance.

See the scientific wording

Plasma Maresin-1 levels are strongly and negatively correlated with fasting insulin (r = -0.579), glucose (r = -0.548), and HOMA-IR (r = -0.599) in obese men, suggesting a close link between inflammation resolution and metabolic health.

Why this might work

When the body breaks down a fat called DHA during physical activity, it makes a molecule called Maresin-1 that turns off chronic inflammation. This allows insulin to work better in muscles, so glucose enters cells more efficiently and blood sugar drops.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: 12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial

    When obese men exercised and took a natural compound called fisetin, their bodies made more Maresin-1 — a molecule that calms inflammation — and their blood sugar and insulin levels got better. This supports the idea that reducing inflammation helps improve metabolic health.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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