The Claim

In malnourished older adults aged 80–92 years, 3 weeks of oral citrulline supplementation (10 g/day) was associated with higher systemic amino acid availability compared to an isonitrogenous placebo of non-essential amino acids, as measured by significantly greater total differences in amino acid and non-essential amino acid area under the curve between fed and postabsorptive states.

Source: Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
46score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In malnourished adults aged 80 to 92, taking 10 grams of citrulline daily for 3 weeks resulted in higher systemic amino acid availability than taking a placebo with non-essential amino acids, as measured by greater differences in amino acid levels between fed and postabsorptive states.

See the scientific wording

In malnourished older adults aged 80–92 years, 3 weeks of oral citrulline supplementation (10 g/day) was associated with higher systemic amino acid availability compared to an isonitrogenous placebo of non-essential amino acids, as measured by significantly greater total differences in amino acid and non-essential amino acid area under the curve between fed and postabsorptive states.

Why this might work

Citrulline is converted into arginine in the kidneys, and arginine is then used to make other amino acids or released into the blood, increasing the total amount of amino acids available in the body after eating.

Supported mechanismbased on 1 study

What the research says

1 study

  1. Study: Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial.

    In older, malnourished people, taking 10 grams of citrulline daily for 3 weeks helped more amino acids stay in the blood after meals compared to a placebo with similar ingredients. This means their bodies had better access to the building blocks needed for muscle and repair.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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