The Claim
In aged male mice, supplementation with apigenin at 50 mg/kg/day for nine months is associated with increased expression of mitochondrial biogenesis genes (PGC-1α, TFAM, NRF-1, ATP5B), indicating an enhanced capacity for mitochondrial biogenesis.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In older male mice, daily apigenin supplementation for nine months increases the activity of genes involved in creating new mitochondria.
See the scientific wording
In aged male mice, apigenin supplementation at 50 mg/kg/day for nine months is associated with increased expression of mitochondrial biogenesis genes (PGC-1α, TFAM, NRF-1, ATP5B), suggesting enhanced capacity for generating new mitochondria.
Apigenin lowers harmful reactive molecules in muscle cells, which protects mitochondria from damage. This allows the cell to activate genes that build new mitochondria, while stopping the over-destruction of existing ones. As a result, more mitochondria are made, and they produce more energy for the muscle.
What the research says
1 studyIn older male mice, giving apigenin made their muscles produce more energy factories (mitochondria) by turning up genes that build them, which helped their muscles get stronger and work better.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.