In older women with diabetes, higher levels of a bone protein called osteocalcin are more strongly linked to weak hand grip than in men — especially when levels are above 15 ng/mL.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

40

Sex Differences and Positive Dose-Response Relationships between Serum Osteocalcin Levels and Low Muscle Strength

Cross-Sectional Study

Human

2023

This study found that in older adults with diabetes, women with higher levels of a bone protein called osteocalcin are much more likely to have weak hand grip than men with the same levels—especially when the protein level is 15 ng/mL or higher.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Sex Differences and Positive Dose-Response Relationships between Serum Osteocalcin Levels and Low Muscle Strength

Score: 40

DOI: 10.1159/000531371

Similar Assertions

The more osteocalcin in the blood of older adults with diabetes, the weaker their hand grip tends to be — and this pattern gets stronger as levels go up.

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People with diabetes who have more osteocalcin in their blood tend to have weaker hand grip, especially women, but we don’t know if the hormone causes weakness or if weakness changes the hormone.

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93%