In one study, drop sets made the top and middle parts of the front thigh muscle grow a bit more than regular sets — but this didn’t happen in other muscles or in other studies, so it’s not clear if it’s real or just a fluke.

In one study, drop sets made the upper and middle parts of the thigh muscle grow more than regular sets, suggesting they might target certain muscle areas better.

Doing leg extensions with drop sets (going to failure, then lowering the weight and going again) makes the front part of your thigh muscle bigger in the upper and middle areas, but not the bottom part or the side muscle.

When you train your quads, drop sets don’t make the outer thigh muscle grow more than regular sets — both methods make it grow about the same.

Doing leg extensions with drop sets (going to failure, then lowering the weight and going again) makes the front part of your thigh muscle grow more than doing regular sets, but only in the upper and middle parts—not the bottom or the side muscles.

Even if you do the same total amount of work, drop sets don’t make your muscles grow more than regular sets — whether you match the weight lifted or not, the results are about the same.