The Claim
Vitamin D supplementation reduces high-density lipoprotein cholesterol (HDL-C) by 2.16 mg/dL in overweight and obese children and adolescents.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In overweight and obese children and adolescents, taking vitamin D supplements lowers HDL cholesterol by 2.16 mg/dL.
See the scientific wording
Vitamin D supplementation significantly reduces high-density lipoprotein cholesterol (HDL-C) by 2.16 mg/dL in overweight and obese children and adolescents, based on a meta-analysis of five randomized controlled trials with 252 participants, a finding that may indicate a potentially harmful metabolic effect.
When vitamin D supplements are taken, the body stores excess vitamin D in fat tissue, which limits how much is available to act on the liver and other organs. This shortage disrupts the process that moves cholesterol out of the blood and back to the liver for removal, causing good cholesterol levels to drop.
What the research says
1 studyThis study found that giving vitamin D supplements to overweight kids and teens slightly lowered their 'good' cholesterol, which is not a good thing for heart health. So yes, the supplements seem to have a small negative effect.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.