The Claim
Vitamin D2 supplementation reduces HOMA-IR by 0.51 units more than vitamin D3 in overweight and obese children and adolescents.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In overweight and obese children and adolescents, vitamin D2 lowers HOMA-IR by 0.51 units more than vitamin D3.
See the scientific wording
Vitamin D2 supplementation may reduce HOMA-IR by 0.51 units more than vitamin D3 in overweight and obese children and adolescents, based on a subgroup analysis of four randomized controlled trials with 227 participants, though this finding is based on low-certainty evidence and may be influenced by bias.
In overweight children and teens, vitamin D2 is less likely to get trapped in fat tissue than vitamin D3, so more of it reaches the liver and kidneys to become active. This active form binds to receptors in muscle and fat cells, turning on genes that help those cells take in sugar from the blood, which lowers insulin resistance.
What the research says
1 studyThis study found that in overweight kids and teens, vitamin D2 might help reduce insulin resistance a little more than vitamin D3, but the result isn’t super strong and could be due to chance or small sample size.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.