The Claim
Mutational signature analysis via whole-genome sequencing detected colibactin-associated signatures SBS88 and ID18 in 39% of adenomas or carcinomas from patients with APC variants, compared to 11% in controls, indicating an association between colibactin-producing bacteria and specific DNA damage patterns in colorectal neoplasms.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Researchers found that DNA damage patterns linked to a specific bacterial toxin were present in 39% of colorectal tumors from individuals with APC gene variants, compared to 11% in individuals without these tumors. This suggests a statistical relationship between the bacterial toxin and the type of DNA damage observed in these cancers.
See the scientific wording
Mutational signature analysis via whole-genome sequencing detected colibactin-associated signatures SBS88 and ID18 in 39% of adenomas or carcinomas from patients with APC variants matching these signatures, compared to 11% in controls, supporting a link between these bacterial genotoxins and specific DNA damage patterns in colorectal neoplasms.
What the research says
1 studyThis study found that people with certain colon growths had DNA damage patterns that match those caused by a harmful gut bacteria called colibactin, and those people were also more likely to have that bacteria in their poop. So yes, the bacteria seems to be leaving a fingerprint in the DNA of these growths.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.