The Claim

In patients with psoriasis, atopic dermatitis, and vitiligo, pathological overexpression of inducible nitric oxide synthase (iNOS) and NADPH oxidase causes peroxynitrite formation, which disrupts the nitric oxide-reactive oxidants balance and impairs antioxidant systems such as Nrf2.

Source: Photo-induced nitric oxide modulation in human skin: Impacts of geographic location and seasonality on health and disease.

What the research says

Roughly balanced

Support and challenge are close. The picture may shift as more studies come in.

Supports
1score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In people with certain skin conditions like psoriasis and eczema, their bodies make too much of two harmful chemicals that combine to create a damaging substance, which throws off their natural balance and weakens their body’s ability to protect itself.

See the scientific wording

In patients with psoriasis, atopic dermatitis, and vitiligo, pathological overexpression of inducible nitric oxide synthase (iNOS) and NADPH oxidase leads to peroxynitrite formation, disrupting the nitric oxide-reactive oxidants balance and impairing antioxidant systems like Nrf2.

What the research says

1 study

  1. Study: Photo-induced nitric oxide modulation in human skin: Impacts of geographic location and seasonality on health and disease.

    In people with certain skin diseases like psoriasis, the body makes too much of two harmful molecules (iNOS and NADPH oxidase) that combine to create a damaging compound (peroxynitrite), which breaks down the skin’s natural defenses. This study shows that’s exactly what happens in these patients.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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