The Claim
In patients with coronary artery disease, perivascular adipose tissue surrounding the left coronary artery trunk and proximal segments of major coronary arteries is significantly thicker than in patients without coronary artery disease, and this increased thickness is correlated with local adipokine dysregulation.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In people with coronary artery disease, the fat tissue around the main heart arteries is thicker than in people without the disease, and this thicker fat tissue is associated with abnormal levels of signaling molecules produced by fat cells.
See the scientific wording
In patients with coronary artery disease, perivascular adipose tissue around the left coronary artery trunk and proximal segments of major coronary arteries is significantly thicker than in patients without coronary disease, and this thickness correlates with local adipokine dysregulation.
When blood flow to the heart muscle is reduced, the fat surrounding the main heart arteries becomes starved of oxygen. This causes fat cells to stop producing a protective chemical and start producing harmful ones. The harmful chemicals inflame the artery walls, attract immune cells, and make plaques more likely to form and break apart.
What the research says
1 studyIn people with heart disease, the fat around their main heart arteries is more inflamed and produces fewer protective chemicals than in healthy people — exactly what the claim says.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.