In a group of people with Crohn’s disease, 58% had high stress, 27% had severe or extremely severe anxiety, and 24% had severe or extremely severe depression, based on a standardized psychological questionnaire.

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Pro

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Against

Evidence from Studies

Supporting (1)

38

Community contributions welcome

38

Hypothalamic-pituitary-adrenal dysregulation and psychological distress in Crohn’s disease: Insights from acute and chronic stress responses

Cross-Sectional Study

Human

This study asked people with Crohn’s disease how stressed, anxious, or depressed they felt, and found that about 6 in 10 felt stressed, 3 in 10 felt very anxious, and 2 in 10 felt very depressed — just like the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Hypothalamic-pituitary-adrenal dysregulation and psychological distress in Crohn’s disease: Insights from acute and chronic stress responses

Score: 38

DOI: 10.5498/wjp.v16.i3.111523

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