The Claim

In patients with heart failure with reduced ejection fraction and type 2 diabetes or prediabetes, baseline epicardial adipose tissue volume is higher in males, those with higher body mass index, coronary artery disease, elevated serum creatinine, larger left ventricular end-diastolic volume, and greater left ventricular mass, indicating that epicardial fat accumulation correlates with established markers of cardiac remodeling and metabolic burden.

Source: Effect of empagliflozin on epicardial adipose tissue volume in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF)

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
69score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In patients with heart failure and diabetes or prediabetes, greater amounts of fat around the heart are consistently observed in individuals with higher body weight, male sex, coronary artery disease, elevated kidney markers, larger heart chambers, and increased heart muscle mass.

See the scientific wording

In patients with heart failure with reduced ejection fraction and type 2 diabetes or prediabetes, baseline epicardial adipose tissue volume is higher in males, those with higher body mass index, coronary artery disease, elevated serum creatinine, larger left ventricular end-diastolic volume, and greater left ventricular mass, indicating that epicardial fat accumulation correlates with established markers of cardiac remodeling and metabolic burden.

Why this might work

Excess fat in the body and strain on the heart cause fat tissue around the heart to grow larger, especially when the heart is already weakened and the kidneys are not working well.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Effect of empagliflozin on epicardial adipose tissue volume in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF)

    In people with heart failure and diabetes or prediabetes, this study found that those who were male, heavier, had heart or kidney problems, or had larger/thicker heart chambers tended to have more fat around their heart — which is exactly what the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

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