quantitative
Analysis v1
Strong Support
In people with high blood pressure, having more of a substance called endothelin-1 in the blood is linked to worse kidney function. When this substance reaches 4 pg/ml, it’s a strong sign their kidneys aren’t filtering blood as well as they should.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients.
Cross-Sectional Study
Human
2009 FebThe study found that higher levels of a protein called endothelin-1 are linked to worse kidney function in people with high blood pressure, and it accurately predicts when kidney function drops below a key threshold.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.