How body chemicals show kidney health in high blood pressure
Endothelin-1 and F2-isoprostane relate to and predict renal dysfunction in hypertensive patients.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Endothelin-1, not oxidative stress or general inflammation, was the strongest predictor of reduced kidney function in hypertensive patients.
Most research emphasizes inflammation (like CRP) as a key driver of organ damage; here, a vasoactive peptide (ET-1) outperformed it significantly.
Practical Takeaways
People with high blood pressure could ask their doctor about biomarkers beyond CRP, especially if kidney health is a concern.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Endothelin-1, not oxidative stress or general inflammation, was the strongest predictor of reduced kidney function in hypertensive patients.
Most research emphasizes inflammation (like CRP) as a key driver of organ damage; here, a vasoactive peptide (ET-1) outperformed it significantly.
Practical Takeaways
People with high blood pressure could ask their doctor about biomarkers beyond CRP, especially if kidney health is a concern.
Publication
Journal
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Year
2008
Authors
S. Cottone, G. Mulè', M. Guarneri, A. Palermo, M. C. Lorito, R. Riccobene, R. Arsena, F. Vaccaro, A. Vadalà, E. Nardi, P. Cusimano, G. Cerasola
Related Content
Claims (3)
In people with high blood pressure, having more of a substance called endothelin-1 in the blood is linked to worse kidney function. When this substance reaches 4 pg/ml, it’s a strong sign their kidneys aren’t filtering blood as well as they should.
For people with high blood pressure, a certain blood marker linked to body stress is closely tied to how well their kidneys are working, and a level of 329 in the blood can spot kidney issues with high accuracy.
For people with high blood pressure, two body chemicals—endothelin-1 and 8-ISO-PGF2alpha—are better at predicting kidney problems than a common inflammation marker, and endothelin-1 is the most accurate of all.