In people with obesity, fat tissue does not increase the activity of two key enzymes—HSL and LPL—after eating, which may lead to abnormal fat processing in the blood and a higher chance of developing...
Mechanism
Synthesis from 1 study
After eating, insulin should tell fat cells to stop releasing fat and start clearing fat from the blood. In obese people, this signal doesn’t work right, so fat keeps leaking out and isn’t removed from the blood. This leads to high fat levels that can clog arteries and raise heart disease risk.
Most probable mechanism
In obese people, after eating, the hormone insulin doesn't properly tell fat cells to stop breaking down fat or to clear fat from the blood. This means too much fat stays in the bloodstream, which can lead to unhealthy fat buildup and increase the chance of heart disease.
Insulin is secreted into the bloodstream in response to nutrient intake after a meal.
Insulin normally binds to receptors on adipocytes to activate signaling pathways that suppress hormone-sensitive lipase (HSL) activity and promote lipoprotein lipase (LPL) translocation and activity.
In obese individuals, these insulin signaling pathways are impaired, resulting in failure to suppress HSL and failure to activate LPL despite normal or elevated insulin levels.
Unsuppressed HSL continues to break down stored triglycerides into free fatty acids, while inactive LPL fails to clear triglycerides from circulating lipoproteins.
Elevated free fatty acids and reduced triglyceride clearance lead to dyslipidemia, characterized by high circulating lipids and altered lipoprotein profiles.
Dyslipidemia contributes to atherosclerotic plaque formation and increases the risk of coronary heart disease.
Evidence from Studies
Supporting (1)
Community contributions welcome
Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.