Among adults with obesity, having little social contact is more closely linked to death from heart disease than feeling lonely, suggesting that the physical absence of social connections may affect...
Mechanism
Synthesis from 1 study
People with obesity who don’t have regular contact with others tend to have higher stress levels in their bodies, which keeps their heart and blood vessels under constant strain. Over time, this leads to damage that raises the risk of heart attacks and strokes — even if they don’t feel lonely.
Most probable mechanism
When people with obesity have few social interactions, their bodies stay in a state of constant low-level stress, which keeps their heart rate and blood pressure higher than normal and triggers inflammation in blood vessels. Over time, this wears down the heart and arteries, making heart attacks and strokes more likely.
Chronic lack of social contact is associated with sustained activation of the sympathetic nervous system, leading to elevated resting heart rate and blood pressure
Sustained sympathetic activation promotes release of pro-inflammatory cytokines from adipose tissue and vascular endothelium
Chronic low-grade inflammation accelerates atherosclerosis and endothelial dysfunction in coronary and systemic arteries
Evidence from Studies
Supporting (1)
Community contributions welcome
Improvement of Social Isolation and Loneliness and Excess Mortality Risk in People With Obesity
Contradicting (0)
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Gold Standard Evidence Needed
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