In people with obesity, insulin doesn’t reduce fat release from fat tissue as well as it does in lean people — but if you account for how much fat they have, insulin works just as well.

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Pro

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Against

Evidence from Studies

Supporting (1)

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Community contributions welcome

33

Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.

Cross-Sectional Study

Human

1992 Jul

This study found that in obese people, insulin doesn’t suppress fat release as well when you look at the whole body — but when you account for how much fat they have, insulin works just as well as in lean people.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.

Score: 33

DOI: 10.1152/AJPENDO.1992.263.1.E79

Similar Assertions

Insulin reduces fat burning in the blood the same way in obese and lean people, but obese people still burn more fat overall because their bodies are burning fat stored inside cells — not just from the blood.

33

0

78%

Obese people re-store more fat inside their cells at rest, and insulin doesn’t slow this process down as much as it does in lean people.

33

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In people with obesity who don’t have diabetes, fat cells still respond normally to insulin — the high fat levels are just because they have more fat tissue, not because their fat cells are broken.

33

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People with obesity have more fat circulating in their blood at rest, and their bodies are breaking down and re-storing fat at a faster rate than people without obesity.

33

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74%