The Claim

Higher fasting C-peptide levels are associated with better cognitive performance on the Montreal Cognitive Assessment, Mini-Mental State Examination, and Frontal Assessment Battery in patients with progressive supranuclear palsy and corticobasal syndrome.

Source: Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
42score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Correlation
1 study reviewed
In plain English

In patients with progressive supranuclear palsy and corticobasal syndrome, higher levels of fasting C-peptide are linked to higher scores on tests of memory, attention, and executive function.

See the scientific wording

Higher levels of fasting C-peptide are associated with better cognitive performance on the Montreal Cognitive Assessment, Mini-Mental State Examination, and Frontal Assessment Battery in patients with progressive supranuclear palsy and corticobasal syndrome, suggesting endogenous insulin secretion may play a protective role in cognition.

Why this might work

Higher natural insulin production protects the brain by helping brain cells use sugar properly, reducing harmful inflammation, and keeping communication between nerve cells stable, which keeps thinking and memory skills stronger in people with certain brain diseases.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study

    In people with rare brain diseases, those with higher natural insulin levels (shown by C-peptide) scored better on memory and thinking tests, suggesting their brain function may be helped by their own insulin production.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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