The Claim
In obese adults with a mean BMI of 46 kg/m², the expression of thyrotropin receptor (TSHR) and thyroid hormone receptor TRα1 in subcutaneous adipose tissue is reduced by 67% and 33%, respectively, compared to lean individuals, and these reductions are reversed by 150% and 70% after 12 months of significant weight loss following gastric bypass surgery.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In obese adults with a BMI of 46, levels of two thyroid-related receptors in fat tissue are 67% and 33% lower than in lean people, and after 12 months of weight loss from gastric bypass surgery, these receptor levels increase by 150% and 70%.
See the scientific wording
In obese adults with a mean BMI of 46 kg/m², the expression of thyrotropin receptor (TSHR) and thyroid hormone receptor TRα1 in subcutaneous adipose tissue is reduced by 67% and 33%, respectively, compared to lean individuals, and these reductions are reversed by 150% and 70% after 12 months of significant weight loss following gastric bypass surgery, suggesting a strong association between adipose tissue mass and local thyroid hormone signaling.
When fat tissue grows large, it reduces the number of thyroid hormone sensors on its cells, making the tissue less responsive to thyroid signals. When fat tissue shrinks, the number of these sensors increases, restoring the tissue's ability to respond to thyroid hormones and improving feedback control over thyroid hormone production in the body.
What the research says
1 studyWhen people with severe obesity lose a lot of weight after surgery, their fat tissue starts producing more of two important thyroid-related proteins it was making less of before — showing that fat mass directly affects how thyroid hormones work locally in the body.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.