In people with stable heart disease, when the proteasome (a cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack.

Scientific Claim

There is a significant inverse correlation between perilipin-2 (PLIN2) protein levels and proteasome activity in patients with chronic coronary syndrome (CCS), with a p-value of 0.018, but this correlation is not observed in ST-elevation myocardial infarction (STEMI) patients.

Original Statement

“a significant inverse correlation was evident between PLIN2 levels and proteasome activity in the CCS group (p = 0.018), while it was not significant in the STEMI group (Figure 3C,D).”

From study:Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and reports a correlation between two variables. The claim appropriately uses 'inverse correlation' which is the correct terminology for this type of relationship.

Evidence from Studies

Supporting (1)

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Cross-Sectional Study

Human

Contradicting (0)

No contradicting evidence found

Source Study

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Score: 37

DOI: 10.3390/ijms26199550

Similar Assertions

In people with stable heart disease, when the proteasome (cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack, suggesting different ways PLIN2 is regulated in these two conditions.

96%

In people having a heart attack, PLIN2 protein stays high even though the cellular cleanup system (proteasome) is more active, suggesting there might be special reasons why PLIN2 isn't being broken down properly during a heart attack.

88%

In people with heart disease, older patients tend to have higher levels of PLIN2 protein in their blood cells, and this relationship is stronger in those with stable heart disease than in those having a heart attack.

86%

In people with stable heart disease, older age is more strongly linked to higher PLIN2 protein levels than in people having a heart attack, suggesting age might affect PLIN2 differently in different types of heart disease.

84%

In people having a heart attack called STEMI, the amount of a protein called PLIN2 in certain blood cells is higher than in people with stable heart disease, which might be related to why their heart attack happened.

84%