In people with heart disease, older patients tend to have higher levels of PLIN2 protein in their blood cells, and this relationship is stronger in those with stable heart disease than in those having a heart attack.

Scientific Claim

Perilipin-2 (PLIN2) protein expression shows a significant positive correlation with age in both ST-elevation myocardial infarction (STEMI) and chronic coronary syndrome (CCS) patients, with r² = 0.09 (p = 0.002) for STEMI and r² = 0.24 (p = 0.014) for CCS, and the difference in these correlations was statistically significant (p = 0.003).

Original Statement

“PLIN2 expression was significantly correlated with age in STEMI (r2 = 0.09; p = 0.002) and CCS patients (r2 = 0.24; p = 0.014) (Figure 5). When performing a univariate analysis of variance, with variable PLIN2 of STEMI and CCS patients in relation to age, with linearly independent pairwise comparisons between the estimated marginal means, the difference in the two correlations was found to be significant (p = 0.003).”

From study:Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and reports correlations between variables. The claim appropriately uses 'significant positive correlation' which is the correct terminology for this type of relationship.

Evidence from Studies

Supporting (1)

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Cross-Sectional Study

Human

Contradicting (0)

No contradicting evidence found

Source Study

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Score: 37

DOI: 10.3390/ijms26199550

Similar Assertions

In people with stable heart disease, older age is more strongly linked to higher PLIN2 protein levels than in people having a heart attack, suggesting age might affect PLIN2 differently in different types of heart disease.

97%

In people having a heart attack called STEMI, the amount of a protein called PLIN2 in certain blood cells is higher than in people with stable heart disease, which might be related to why their heart attack happened.

89%

In people with stable heart disease, when the proteasome (a cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack.

86%

In people with stable heart disease, when the proteasome (cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack, suggesting different ways PLIN2 is regulated in these two conditions.

82%

The types and amounts of fats inside blood cells were similar between people having a heart attack and those with stable heart disease, even though the PLIN2 protein levels were different between these groups.

81%