The types and amounts of fats inside blood cells were similar between people having a heart attack and those with stable heart disease, even though the PLIN2 protein levels were different between these groups.

Scientific Claim

No significant differences were found in monocyte lipid composition between ST-elevation myocardial infarction (STEMI) and chronic coronary syndrome (CCS) patients (p = n.s.) despite significant differences in perilipin-2 (PLIN2) protein levels between the groups.

Original Statement

“We found no significant difference in monocyte lipid content between the two patient groups.”

From study:Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study is observational and reports no significant difference between groups. The claim appropriately states the finding without implying causation.

Evidence from Studies

Supporting (1)

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Cross-Sectional Study

Human

Contradicting (0)

No contradicting evidence found

Source Study

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications

Score: 37

DOI: 10.3390/ijms26199550

Similar Assertions

In people having a heart attack called STEMI, the amount of a protein called PLIN2 in certain blood cells is higher than in people with stable heart disease, which might be related to why their heart attack happened.

87%

In people with stable heart disease, older age is more strongly linked to higher PLIN2 protein levels than in people having a heart attack, suggesting age might affect PLIN2 differently in different types of heart disease.

82%

In people with heart disease, older patients tend to have higher levels of PLIN2 protein in their blood cells, and this relationship is stronger in those with stable heart disease than in those having a heart attack.

81%

In people with stable heart disease, when the proteasome (a cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack.

80%

In people with stable heart disease, when the proteasome (cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack, suggesting different ways PLIN2 is regulated in these two conditions.

78%